Phenotypic screening techniques for Cryptosporidium drug discovery

Phenotypic Drug Discovery with High Content Screening

Drug discovery in its early history used to be conducted mainly in a target-agnostic fashion, focusing on qualitative readouts from a living system -cells, tissue, or organisms -and asking the question, ‘Did this entity affect the phenotype?’. With the rise of molecular biology in the early 1980s and an ever more powerful genomics toolkit from the 1990s, there was a marked shift away from pheno...

A novel phenotypic screening platform targeting chronic pain drug discovery

Chronic pain is a disease area with a significant and unmet need for improved treatments. However, due to the complex nature of pain transduction, pain is a notoriously difficult area for drug discovery, where conventional target-based efforts have largely failed to produce new drugs. In this whitepaper, we present a novel phenotypic screening platform based on our proprietary Cellaxess® Elektr...

NMR screening techniques in drug discovery and drug design

Drug Discovery for Neglected Diseases: Molecular Target-Based and Phenotypic Approaches Miniperspectives Series on Phenotypic Screening for Antiinfective Targets

Drug discovery for neglected tropical diseases is carried out using both target-based and phenotypic approaches. In this paper, target-based approaches are discussed, with a particular focus on human African trypanosomiasis. Target-based drug discovery can be successful, but careful selection of targets is required. There are still very few fully validated drug targets in neglected diseases, an...

Next Generation Phenotypic Screening: Part of a balanced strategy for accelerating drug discovery

Historically, drug discovery has employed mainly “phenotypic” approaches—often characterized by physiological observations on whole animals or organ models (Kotz 2012). Most of the first-in-class medicines, those that use a unique mechanism of action to treat a medical condition, developed before the 1980s were discovered by phenotypic Executive Summary With the advent of increasingly high thro...